In the face of unresponsive domestic legal and political systems, the Indian Law Resource Center partnered with Native women’s organizations and Indian nations on a national strategy – a strategy reframing the issue of violence against Native women as a human rights issue, not just a domestic or law enforcement issue. By combining domestic and international advocacy and turning to the international human rights arena to find justice, this strategy has led to encouraging results. A new handbook by the Indian Law Resource Center documents advocacy within the Inter-American Human Rights System to combat violence against Native women in the United States. We hope this resource contributes to the hard work that remains to ensure that all indigenous peoples can fully enjoy their human rights.